Jason W Chien Selected Research

presatovir

12/2020	A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Lower Respiratory Tract.
12/2020	A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients.
10/2020	Drug Resistance Assessment Following Administration of Respiratory Syncytial Virus (RSV) Fusion Inhibitor Presatovir to Participants Experimentally Infected With RSV.
1/2020	Assessment of Drug Resistance during Phase 2b Clinical Trials of Presatovir in Adults Naturally Infected with Respiratory Syncytial Virus.
8/2018	Phase 1 First-in-Human, Single- and Multiple-Ascending Dose, and Food Effect Studies to Assess the Safety, Tolerability, and Pharmacokinetics of Presatovir for the Treatment of Respiratory Syncytial Virus Infection.
1/2018	The Drug-Drug Interaction Profile of Presatovir.
8/2015	Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection.
8/2014	Oral GS-5806 activity in a respiratory syncytial virus challenge study.

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Jason W Chien Research Topics

Disease

9	Respiratory Syncytial Virus Infections 12/2020 - 04/2013
9	Bronchiolitis Obliterans Syndrome 01/2020 - 04/2006
6	Lung Neoplasms (Lung Cancer) 01/2013 - 04/2007
5	Neoplasms (Cancer) 01/2020 - 04/2007
5	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2011 - 01/2008
4	Respiratory Insufficiency (Respiratory Failure) 12/2020 - 08/2005
4	Respiratory Tract Infections (Respiratory Tract Infection) 12/2020 - 01/2017
3	Idiopathic Pulmonary Fibrosis 01/2017 - 05/2013
3	Pneumonia (Pneumonitis) 01/2017 - 10/2005
2	Bronchiolitis Obliterans 01/2020 - 07/2009
2	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 01/2008
2	Infections 08/2015 - 04/2006
2	Disease Progression 05/2014 - 05/2013
2	Chronic Obstructive Pulmonary Disease (COPD) 04/2009 - 04/2007
2	Aspergillosis 10/2008 - 06/2008
1	Lymphopenia (Lymphocytopenia) 12/2020
1	Sleepiness 01/2018
1	Dizziness (Lightheadedness) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2017
1	Cough 01/2017
1	Body Weight (Weight, Body) 08/2015
1	Pulmonary Hypertension 05/2013
1	Respiratory Tract Diseases (Respiratory Tract Disease) 04/2013
1	Bronchiectasis 07/2012
1	Organizing Pneumonia 07/2012
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2011
1	Residual Neoplasm 03/2011
1	Paramyxoviridae Infections (Parainfluenza) 05/2010
1	Human Influenza (Influenza) 05/2010
1	Coinfection 05/2010
1	Lung Diseases (Lung Disease) 02/2010
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2009
1	Invasive Fungal Infections 06/2008
1	Bacteremia 02/2008
1	Inflammation (Inflammations) 01/2008
1	Asbestosis 12/2007
1	Virus Diseases (Viral Diseases) 06/2006
1	Muscular Diseases (Myopathy) 04/2006
1	Osteoporosis 04/2006
1	Cytopenia 07/2005

Drug/Important Bio-Agent (IBA)

8	presatovirIBA 12/2020 - 08/2014
4	Oxygen (Dioxygen)IBA 12/2020 - 08/2005
4	Azithromycin (Zithromax)FDA LinkGeneric 01/2020 - 04/2016
3	Antiviral Agents (Antivirals)IBA 12/2020 - 08/2015
3	Progestins (Progestagens)IBA 09/2010 - 10/2009
3	Hormones (Hormone)IBA 09/2010 - 10/2009
2	Ribavirin (Virazole)FDA LinkGeneric 12/2020 - 04/2013
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2017
2	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2017 - 05/2014
2	CollagenIBA 01/2017 - 05/2014
2	Fluticasone (Cutivate)FDA LinkGeneric 11/2016 - 04/2016
2	montelukast (Singulair)FDA Link 11/2016 - 04/2016
2	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2011 - 04/2007
2	Estrogens (Estrogen)FDA Link 09/2010 - 03/2010
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2018
1	Organic Anion TransportersIBA 01/2018
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	efavirenz (Sustiva)FDA Link 01/2018
1	Cytochrome P-450 CYP3AIBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	Coenzyme A (CoA)IBA 01/2017
1	simtuzumabIBA 01/2017
1	ambrisentan FDA Link 05/2013
1	MicroRNAs (MicroRNA)IBA 01/2013
1	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 05/2011
1	Conjugated (USP) Estrogens (Premarin)FDA Link 09/2010
1	RNA (Ribonucleic Acid)IBA 05/2010
1	Viral RNAIBA 05/2010
1	VitaminsIBA 03/2010
1	SmokeIBA 04/2009
1	Interleukin-10 (Interleukin 10)IBA 03/2009
1	HLA Antigens (Human Leukocyte Antigens)IBA 03/2009
1	Toll-Like Receptor 4IBA 10/2008
1	PlasminogenIBA 06/2008
1	lipopolysaccharide-binding proteinIBA 02/2008
1	AntigensIBA 01/2008
1	AsbestosIBA 12/2007
1	Bronchodilator Agents (Bronchodilators)IBA 04/2007
1	SteroidsIBA 04/2006
1	Carbon MonoxideIBA 08/2005
1	Interleukin-12 (IL 12)IBA 07/2005
1	Interferon-gamma (Interferon, gamma)IBA 07/2005

Therapy/Procedure

11	Cell Transplantation 01/2020 - 06/2006
7	Therapeutics 10/2020 - 04/2006
7	Hematopoietic Stem Cell Transplantation 07/2012 - 01/2008
4	Transplantation 07/2011 - 10/2005
2	Artificial Respiration (Mechanical Ventilation) 12/2020 - 05/2010
2	Stem Cell Transplantation 10/2008 - 08/2005
1	Intravenous Administration 08/2015
1	Traction 07/2012
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 03/2010
1	Lung Transplantation 01/2010